Table 3.

SNPs with p Value ≤ .01 in the LRT for Allelic Association

Gene	SNP rs #	Alleles [A1/A2]	Group	Allele Frequencies		Allelic LRT p	Diagnostic Group
				A1	A2
ALAD	rs818702	A/G	Cases	.884	.116	.008	SOCPHa
			Controls	.761	.239
CDH2	rs7240351b	A/G	Cases	.333	.667	.006	SOCPHc
			Controls	.488	.513
EPB41L4A	rs7719346	A/G	Cases	.140	.860	.008	GADa
			Controls	.248	.752
	rs1464766	A/G	Cases	.255	.745	.010	PD
			Controls	.350	.651
	rs12657885b	C/T	Cases	.918	.083	.010	GADc
			Controls	.849	.151
PSAP	rs4746097	C/T	Cases	.729	.271	.004	PD
			Controls	.616	.384
	rs11597008b	C/T	Cases	.615	.385	.008	PD
			Controls	.502	.498
PTGDS	rs4880179	A/G	Cases	.053	.947	.010	GADc
			Controls	.015	.985

Empirical p values from 10,000 permutations are shown. SNP, single nucleotide polymorphism; LRT, likelihood-ratio test; SOCPH, social phobia; GAD, generalized anxiety disorder; PD, panic disorder; refer to Table 2 for gene names.

^aDSM-IV core diagnosis.

^bRs-numbers of markers genotyped in stage II.

^cDSM-IV extended diagnosis.