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FRET between PS1 loop and APP CT in CHOSw compared to NcadCHOSw cells
| cell line | FRET donor (Alexa 488) | FRET acceptor (Cy3) | Alexa 488 lifetime in ps (mean ± S.E.) | p value (compared with CHOSw PS1 loop APP CT) |
|---|---|---|---|---|
| APPSw-CHO (n = 10) | PS1 loop | None (negative control) | 1932+/−7 | p < 0.0001 |
| APPSw-CHO (n = 10) | PS1 loop | APP CT | 1790 ± 22 | |
| APPSw/Ncad-CHO (n = 12) | PS1 loop | APP CT | 1644 ± 25 | p < 0.0001 |
