TABLE 2.

TABLE 2-1. FRET between PS1 N-terminus and APP CT in NcadCHOSw cells treated with N-cadherin neutralizing GC-4 antibody or IgG as a control
cell line	FRET donor (Alexa 488)	FRET acceptor (Cy3)	Alexa 488 lifetime in ps (mean ± S.E.)	p value (compared with control IgG)
NcadCHOSw (Negative Control)	PS1 NT	None	1903±28
NcadCHOSw with control IgG (n = 21)	PS1 NT	APP CT	1677 ± 22
NcadCHOSw with GC-4 (n = 17)	PS1 NT	APP CT	1789 ± 100	p < 0.01

TABLE 2-2. FRET between PS1 loop and APP CT in living NcadCHOSw cells treated with GC-4 or IgG
cell line	FRET donor	FRET acceptor	Alexa 488 lifetime in ps (mean ± S.E.)	p value (compared with control IgG)
NcadCHOSw (Negative Control)	APP-GFP	None	2076±62
NcadCHOSw with control IgG (n = 21)	APP-GFP	PS1-RFP(loop)	1646 ± 223
NcadCHOSw with GC-4 (n = 17)	APP-GFP	PS1-RFP(loop)	1859 ± 74	p < 0.01