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The effect of rare arginine codons on regulation by uORF2. The rare arginine codons (at positions 3 and 4) in uORF2 were either changed to common arginine codons (CGC-CGC in construct pBC224a) or to common alanine codons (GCA-GCA in construct pBC226d). The relative luciferase activities indicate that both the synonymous and the missense mutations of the rare arginine codons result in a 3- to 4-fold increase in translation of the downstream reporter.
