Table 1.
Metabolic traits by PKLR region haplotype combination
| Trait | Hom-C | Heterozygous | Hom-R | P value |
|---|---|---|---|---|
| n (M/F) | 128 (45/83) | 113 (43/70) | 14 (2/12) | |
| Age (yr) | 38.2 (9.6) | 36.9 (9.3) | 39.3 (5.6) | 0.4 |
| BMI (kg/m2) | 30.0 (6.3) | 29.2 (5.6) | 32.9 (5.0) | 0.067 |
| % Body fat | 35.6 (9.0) | 33.9 (9.6) | 40.9 (6.3) | 0.021 |
| Waist-hip ratio | 0.89 (0.08) | 0.89 (0.08) | 0.90 (0.08) | 0.91 |
| Systolic BP (mm Hg) | 117 (12) | 117 (12) | 115 (11) | 0.88 |
| Diastolic BP (mm Hg) | 77 (12) | 77 (8) | 75 (9) | 0.67 |
| Total cholesterol (mmol/liter) | 4.68 (4.53, 4.86) | 4.50 (3.44, 4.68) | 4.81 (4.34, 5.35) | 0.24 |
| Triglycerides (mmol/liter) | 1.21 (1.11, 1.32) | 1.21 (1.11, 1.32) | 1.34 (1.04, 1.73) | 0.64 |
| HDL cholesterol (mmol/liter) | 1.25 (1.20, 1.31) | 1.23 (1.71, 1.29) | 1.20 (1.06, 1.36) | 0.72 |
| LDL cholesterol (mol/liter) | 2.74 (2.59, 2.87) | 2.90 (2.64, 3.18) | 3.08 (2.38, 3.96) | 0.12 |
| SI (× 10−4 min−1 [μU/ml]−1) | 3.18 (2.84, 3.56) | 3.43 (3.00, 3.91) | 3.09 (2.15, 4.44) | 0.65 |
| AIRg (pmol-min/liter) | 2190 (1908, 2514) | 2100 (1824, 2418) | 2070 (1254, 3414) | 0.90 |
| Sg | 0.0173 (0.006) | 0.0183 (0.007) | 0.0172 (0.007) | 0.54 |
| Disposition index | 1131 (981, 1304) | 1199 (1030, 1394) | 1064 (582, 1944) | 0.80 |
| AIRmax (pmol/liter) | 1470 (1260, 1710) | 1164 (984, 1386) | 1380 (762, 2508) | 0.27 |
Traits are shown for combinations of extended haplotypes: Hom-C, common homozygotes; Heterozygotes; and Hom-R, rare haplotype homozygotes. Recombinant haplotypes were assigned to the closest common haplotype. Data are shown as mean (sd) for normal or near normal data, or as geometric mean (95% confidence interval) for nonnormal data. AIRmax was available in only 106 subjects. M, Males; F, females; BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SI, minimal model-derived insulin sensitivity; AIRg, insulin area under curve from 2 to 20 min after glucose bolus; Sg, glucose effectiveness; AIRmax, insulin area under curve after maximally stimulated arginine bolus.