Table 3.
Euglycemic clamp studies by PKLR region haplotype
| Trait | Homozygous common | Heterozygous | Homozygous rare | P value |
|---|---|---|---|---|
| Gender (M/F) | 6/7 | 2/8 | 0/5 | |
| Age (yr) | 40.1 (6.8) | 39.8 (8.4) | 43.8 (2.39) | 0.5 |
| BMI (kg/m2) | 35.1 (3.1) | 34.6 (5.4) | 31.0 (4.6) | 0.2 |
| % Fat | 42.2 (6.4) | 42.4 (4.7) | 41.5 (6.0) | 0.8 |
| Waist-hip ratio | 0.956 (0.075) | 0.924 (0.074) | 0.921 (0.99) | 0.5 |
| Systolic BP (mm Hg) | 120.0 (11.4) | 119.6 (12.9) | 119.4 (11.3) | 0.9 |
| Diastolic BP (mm Hg) | 79.6 (8.0) | 73.7 (9.1) | 75.7 (8.4) | 0.07 |
| Basal HGP (μmol/kg-FFM/min) | 31.8 (7.1) | 29.1 (6.6) | 32.5 (8.9) | 0.6 |
| Insulin-sup. HGP (μmol/kg-FFM/min) | 14.9 (9.9) | 13.6 (7.4) | 40.3 (20.1) | 0.023 |
| GD (μmol/kg -FFM/min) | 35.6 (19.3) | 36.4 (15.9) | 76.6 (25.0) | 0.014 |
| Ox GD (μmol/kg-FFM/min) | 22.3 (5.8) | 23.5 (6.9) | 28.2 (4.2) | 0.09 |
| Nonox GD (μmol/kg-FFM/min) | 13.2 (14.6) | 12.9 (9.7) | 48.5 (22.9) | 0.008 |
Demographic and phenotypic data for 28 individuals recruited for euglycemic clamp studies. P values are based on ANOVA, with natural or common logarithmic transformation where required. All significant values were also significant without transformation. M, Male; F, female; BP, blood pressure; HGP, hepatic glucose production; Insulin-sup. HGP, hepatic glucose production during hyperinsulinemic portion of clamp; GD, glucose disposal, shown normalized for fat free mass (FFM); Ox GD, oxidative glucose disposal; Nonox GD, nonoxidative glucose disposal. All measures of glucose disposal and hepatic glucose production are shown normalized to fat free mass (FFM: μmol/kg-FFM/min).