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. 2009 Jan 21;94(4):1451–1457. doi: 10.1210/jc.2008-1223

Figure 5.

Figure 5

The rs4238001 (G2S) variant is associated with alterations in SR-BI protein translation and degradation, but not SR-BI mRNA transcription. A, Transcription of SR-BI RNA was similar in rabbit reticulocytes transfected with plasmids expressing either SR-BI wild-type (WT) or GS2 variant. B, Translation of SR-BI protein was reduced in rabbit reticulocytes transfected with plasmids expressing the G2S variant. C, Stably expressing wild-type and G2S variant murine RAW macrophages were incubated with cycloheximide (140 μg/ml) for varying periods of time (0–7 h). SR-BI turnover was significantly greater in G2S cells by 4 and 7 h compared with wild-type cells (P < 0.0007 and P < 0.04, respectively). *, P < 0.0007 and **, P < 0.04 compared to murine RAW macrophages transfected with wild-type SR-BI.