Table 6. Effects of loci on multiple lipoprotein or lipid traits.
| SNP | Locus | Nearest gene(s) | Allele (frequency)a | LDL cholesterolb | HDL cholesterol | Triglycerides |
|---|---|---|---|---|---|---|
| Newly identified loci | ||||||
| rs646776 | 1p13 | CELSR2, PSRC1, SORT1 | C (0.24) | ↑ | ||
| rs16996148 | 19p13 | CILP2, PBX4, GALNT2 | T (0.10) | ↓ | ↓ | |
| rs4846914 | 1q42 | G (0.40) | ↓ | ↑ | ||
| rs17145738 | 7q11 | BCL7B, TBL2, MLXIPL | T (0.13) | ↑ | ↓ | |
| rs17321515 | 8q24 | TRIB1 | G (0.49) | ↓ | ↑ | ↓ |
| rs12130333 | 1p31 | ANGPTL3, DOCK7, ATG4C | T (0.22) | ↓ | ||
| Selected loci with prior evidence | ||||||
| rs693 | 2p24 | APOB | A (0.48) | ↑ | ↑ | |
| rs28927680 | 11q23 |
AP0A1-C3-A4-A5, ZNF259, BUD13 |
G (0.07) | ↓ | ↑ | |
| rs328 | 8p21 | LPL | G (0.09) | ↑ | ↓ | |
We required each new locus to be associated with at least one lipoprotein or lipid trait at a genome-wide association threshold (P ≤ 5 × 10−8). We did not require the associations with the second and/or third trait to be at this threshold.
a
Alleles for the SNP on the forward strand of human genome reference sequence (National Center for Biotechnology Information Build 35) were modeled. Allele frequency in the MDC-CC replication sample is presented.
b
↑ indicates that the modeled allele increases trait value;↓, lowers trait value. Allele shown in column 4 is modeled. Data derived from a combined analysis of DGI and three replication studies, as described in Table 2.