Fig. 1.

Spatial AID-catalyzed mutation distribution in the Jh4 intron in vitro and in vivo. The distribution of mutations along the length of the sequence (horizontal axis) for the top (A) and bottom (B) strands is shown. Each graph compares in vivo (vertical axis, upwards) with in vitro (vertical axis, downwards) by showing the percentage of sequences mutated at each site. WRC hot spots and SYC cold spots (GYW and GRS on the bottom strand) are highlighted as shown. Note that both the leftmost 60 nt on the top strand and rightmost 60 nt on the bottom strand shown here were removed for the subsequent analysis.