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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Mutat Res. 2008 Oct 17;660(1-2):1–11. doi: 10.1016/j.mrfmmm.2008.09.017

Fig. 1. Diagram of constructs containing BRCA1 variants analyzed in this study.

Fig. 1

A. Location of missense variants (black arrowhead), positive control (grey arrowhead) and negative controls (open arrowheads). Grey boxes indicate the DNA binding domain (of GAL4 or LexA, depending on the construct) and the BRCT domains. B. Construct containing in-frame deletion Δ exons 16/17. Diagram shows the region that is left out after splicing of exon 15 to exon 18, disrupting the BRCT-N. C. Construct containing variant 5673insC with site of insertion indicated (black arrowhead). Bottom panel shows detail of wild type and mutant amino acid sequence.