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Ganglioside-induced DC apoptosis is caspase dependent. To test whether a caspase-dependent pathway is involved in DC apoptosis, (A) PARP cleavage was detected. GM3- and GD3-induced apoptosis increased cleavage of PARP. (B) The apoptosis of DC was detected also with an Annexin/PI kit. The broad inhibitor of caspase Z-Vad was added every 2 days to the cell cultures both in the presence or absence of gangliosides. (C) GM3- and GD3-induced apoptosis increased caspase 3 activation.
