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. 2009 May 27;4(5):e5704. doi: 10.1371/journal.pone.0005704

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Leemans et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Tubular injury was semi-quantitatively scored using PAS-D stained renal tissue sections. Tubular damage was similar between TLR2^+/+ (□) and TLR2^−/− (▪) mice at all time points. Fibrosis was quantitatively scored by measuring renal collagen accumulation in TLR2^+/+ and TLR2^−/− mice 3, 7, and 14 days after UUO or in contralateral kidneys. This revealed that fibrosis was comparable in kidney of TLR2^−/− mice compared with TLR2^+/+ animals during UUO-induced injury. The percentage of positive staining for collagen (picrosirius red staining), collagen type I and III was analyzed in both cortex and medulla using a computer-assisted digital analysis program. Data are mean and SEM of six mice per group, *p<0.05.