Figure 7. Expression (A) and activity (B) of the MMP-mediated collagen degradation pathway in TLR2^+/+ (□) and TLR2^−/− (▪) mice 3, 7, and 14 days after UUO or in contralateral non-obstructed kidneys.

Both MMPs and TIMPs were significantly reduced in TLR2^−/− mice compared to TLR2^+/+ mice 14 days after UUO-injury (A). Data are mean and SEM of six mice per group, *p<0.05. Gel zymography (B) illustrates that renal MMP-9 activity was lower in kidneys TLR2^−/− mice at this time point. No difference between TLR2^−/− and TLR2^+/+ mice was observed for MMP-2 activity at 14 days post-UUO.