TABLE 2.
Genotypic means for quantitative measures of glucose homeostasis calculated in set 1 of the IRASFS Hispanic-American population
| Phenotype | SNP | Alleles† | MAF | Genotypic means ± SD (n)* |
P‡ | ||
|---|---|---|---|---|---|---|---|
| 1/1 | 1/2 | 2/2 | |||||
| SI | rs1037257 | C/T | 0.37 | 2.37 ± 2.21 (207) | 1.96 ± 1.59 (280) | 2.13 ± 2.17 (85) | 0.027 |
| rs4969076 | C/G | 0.22 | 2.13 ± 2.01 (315) | 2.05 ± 1.69 (198) | 2.24 ± 2.21 (30) | 0.98 | |
| rs1037260 | T/G | 0.13 | 2.09 ± 1.90 (470) | 2.25 ± 2.05 (94) | 2.18 ± 1.74 (5) | 0.40 | |
| rs11077670 | G/A | 0.14 | 2.09 ± 1.98 (398) | 2.22 ± 1.86 (139) | 2.01 ± 2.12 (8) | 0.91 | |
| rs1868486 | G/T | 0.30 | 2.23 ± 2.06 (254) | 2.10 ± 1.92 (232) | 1.81 ± 1.56 (73) | 0.0040 | |
| rs714925 | A/G | 0.30 | 2.19 ± 2.03 (244) | 2.07 ± 1.89 (243) | 1.76 ± 1.45 (71) | 0.011 | |
| rs998571 | A/G | 0.29 | 2.24 ± 2.01 (261) | 2.14 ± 1.97 (219) | 1.71 ± 1.43 (73) | 0.0040 | |
| rs7220818 | A/G | 0.37 | 1.93 ± 1.67 (216) | 2.11 ± 1.94 (268) | 2.71 ± 2.33 (91) | 0.0020 | |
| rs6501603 | T/G | 0.48 | 2.27 ± 2.16 (152) | 2.03 ± 1.86 (276) | 2.15 ± 1.72 (128) | 0.51 | |
| rs4969017 | T/C | 0.03 | 2.14 ± 1.97 (529) | 1.96 ± 1.13 (20) | 1.01 ± 0.00 (1) | 0.18 | |
| AIR | rs1037257 | C/T | 0.37 | 713 ± 543 (207) | 743 ± 619 (280) | 845 ± 721 (85) | 0.54 |
| rs4969076 | C/G | 0.22 | 788 ± 623 (315) | 698 ± 585 (198) | 820 ± 627 (30) | 0.29 | |
| rs1037260 | T/G | 0.13 | 763 ± 644 (470) | 761 ± 566 (94) | 513 ± 177 (5) | 0.69 | |
| rs11077670 | G/A | 0.14 | 770 ± 620 (398) | 676 ± 698 (139) | 920 ± 737 (8) | 0.17 | |
| rs1868486 | G/T | 0.30 | 727 ± 532 (254) | 801 ± 706 (232) | 755 ± 696 (73) | 0.80 | |
| rs714925 | A/G | 0.30 | 728 ± 532 (244) | 800 ± 699 (243) | 751 ± 708 (71) | 0.81 | |
| rs998571 | A/G | 0.29 | 722 ± 525 (261) | 812 ± 724 (219) | 774 ± 699 (73) | 0.66 | |
| rs7220818 | A/G | 0.37 | 788 ± 643 (216) | 739 ± 637 (268) | 736 ± 567 (91) | 0.66 | |
| rs6501603 | T/G | 0.48 | 759 ± 584 (152) | 764 ± 650 (276) | 702 ± 581 (128) | 0.72 | |
| rs4969017 | T/C | 0.03 | 765 ± 626 (529) | 579 ± 297 (20) | 195 ± 0 (1) | 0.14 | |
| DI | rs1037257 | C/T | 0.37 | 1,375 ± 1,279 (207) | 1,225 ± 1,201 (280) | 1,390 ± 1,345 (85) | 0.053 |
| rs4969076 | C/G | 0.22 | 1,397 ± 1,414 (315) | 1,130 ± 893 (198) | 1,553 ± 1,539 (30) | 0.34 | |
| rs1037260 | T/G | 0.13 | 1,273 ± 1,229 (470) | 1,485 ± 1,409 (94) | 1,207 ± 1,052 (5) | 0.62 | |
| rs11077670 | G/A | 0.14 | 1,344 ± 1,309 (398) | 1,133 ± 1,027 (139) | 1,655 ± 1,780 (8) | 0.036 | |
| rs1868486 | G/T | 0.30 | 1,360 ± 1,349 (254) | 1,342 ± 1,283 (232) | 1,027 ± 939 (73) | 0.0020 | |
| rs714925 | A/G | 0.30 | 1,348 ± 1,337 (244) | 1,327 ± 1,202 (243) | 979 ± 838 (71) | 0.0010 | |
| rs998571 | A/G | 0.29 | 1,352 ± 1,292 (261) | 1,388 ± 1,366 (219) | 994 ± 837 (73) | 0.0010 | |
| rs7220818 | A/G | 0.37 | 1,254 ± 1,176 (216) | 1,262 ± 1,280 (268) | 1,597 ± 1,404 (91) | 0.052 | |
| rs6501603 | T/G | 0.48 | 1,463 ± 1,437 (152) | 1,230 ± 1,176 (276) | 1,227 ± 1,004 (128) | 0.68 | |
| rs4969017 | T/C | 0.03 | 1,328 ± 1,293 (529) | 1,100 ± 975 (20) | 197 ± 0 (1) | 0.94 | |
| FBG | rs1037257 | C/T | 0.37 | 93.28 ± 9.35 (220) | 93.85 ± 10.25 (298) | 92.88 ± 9.68 (88) | 0.62 |
| rs4969076 | C/G | 0.22 | 93.57 ± 10.24 (343) | 93.69 ± 9.01 (202) | 91.16 ± 8.15 (32) | 0.043 | |
| rs1037260 | T/G | 0.13 | 93.26 ± 9.55 (498) | 94.35 ± 10.48 (99) | 94.07 ± 11.80 (7) | 0.14 | |
| rs11077670 | G/A | 0.14 | 93.57 ± 9.99 (427) | 93.38 ± 9.49 (144) | 96.31 ± 11.29 (8) | 0.41 | |
| rs1868486 | G/T | 0.30 | 92.49 ± 9.70 (272) | 94.62 ± 10.02 (243) | 94.24 ± 9.35 (77) | 0.019 | |
| rs714925 | A/G | 0.30 | 92.34 ± 9.52 (264) | 94.48 ± 10.00 (253) | 94.05 ± 9.58 (75) | 0.005 | |
| rs998571 | A/G | 0.29 | 92.41 ± 9.48 (280) | 94.24 ± 10.27 (230) | 94.23 ± 9.32 (77) | 0.014 | |
| rs7220818 | A/G | 0.37 | 93.86 ± 9.46 (222) | 93.88 ± 10.00 (286) | 90.96 ± 9.23 (101) | 0.014 | |
| rs6501603 | T/G | 0.48 | 93.30 ± 9.76 (166) | 94.12 ± 10.37 (293) | 92.52 ± 8.86 (132) | 0.25 | |
| rs4969017 | T/C | 0.03 | 93.50 ± 9.69 (562) | 90.59 ± 9.68 (22) | 93.00 ± 0.00 (1) | 0.19 | |
Boldface data indicate P values <0.05.
*Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).
†Major/minor alleles.
‡Test for association among each SNP-trait combination using a series of generalized estimating equations.