TABLE 3.
Phenotype | SNP | Alleles† | MAF | Genotypic means ± SD (n)* |
P‡ | ||
---|---|---|---|---|---|---|---|
1/1 | 1/2 | 2/2 | |||||
SI | rs1037257 | C/T | 0.40 | 2.35 ± 1.78 (143) | 2.08 ± 1.78 (218) | 2.34 ± 1.91 (61) | 0.60 |
rs4969076 | C/G | 0.22 | 2.31 ± 1.85 (34) | 2.15 ± 1.75 (162) | 1.82 ± 1.53 (25) | 0.15 | |
rs1037260 | T/G | 0.15 | 2.19 ± 1.72 (330) | 2.28 ± 1.99 (92) | 3.19 ± 1.55 (2) | 0.83 | |
rs11077670 | G/A | 0.10 | 2.29 ± 1.84 (318) | 1.96 ± 1.69 (88) | 1.81 ± 1.57 (6) | 0.039 | |
rs1868486 | G/T | 0.28 | 2.24 ± 1.78 (199) | 2.23 ± 1.79 (191) | 1.68 ± 1.72 (36) | 0.038 | |
rs714925 | A/G | 0.28 | 2.27 ± 1.81 (196) | 2.25 ± 1.79 (191) | 1.69 ± 1.75 (35) | 0.097 | |
rs998571 | A/G | 0.25 | 2.26 ± 1.79 (214) | 2.21 ± 1.79 (178) | 1.70 ± 1.64 (36) | 0.11 | |
rs7220818 | A/G | 0.41 | 2.17 ± 1.72 (132) | 2.20 ± 1.76 (219) | 2.18 ± 1.85 (72) | 0.98 | |
rs6501603 | T/G | 0.45 | 2.35 ± 1.79 (141) | 2.11 ± 1.77 (203) | 2.22 ± 1.92 (73) | 0.61 | |
rs4969017 | T/C | 0.02 | 2.21 ± 1.79 (417) | 2.00 ± 1.66 (16) | 0.15 | ||
AIR | rs1037257 | C/T | 0.40 | 697 ± 629 (143) | 820 ± 739 (218) | 841 ± 695 (61) | 0.32 |
rs4969076 | C/G | 0.22 | 773 ± 664 (234) | 748 ± 692 (162) | 776 ± 829 (25) | 0.80 | |
rs1037260 | T/G | 0.15 | 740 ± 681 (330) | 867 ± 712 (92) | 455 ± 6 (2) | 0.34 | |
rs11077670 | G/A | 0.10 | 773 ± 641 (318) | 815 ± 886 (88) | 831 ± 358 (6) | 0.84 | |
rs1868486 | G/T | 0.28 | 773 ± 676 (199) | 797 ± 727 (191) | 618 ± 593 (36) | 0.021 | |
rs714925 | A/G | 0.28 | 777 ± 671 (196) | 794 ± 727 (191) | 629 ± 605 (35) | 0.089 | |
rs998571 | A/G | 0.25 | 786 ± 660 (214) | 777 ± 740 (178) | 643 ± 596 (36) | 0.26 | |
rs7220818 | A/G | 0.41 | 757 ± 626 (132) | 789 ± 744 (219) | 747 ± 646 (72) | 0.86 | |
rs6501603 | T/G | 0.45 | 709 ± 602 (141) | 781 ± 708 (203) | 933 ± 837 (73) | 0.66 | |
rs4969017 | T/C | 0.02 | 744 ± 661 (417) | 1,236 ± 1,130 (16) | 0.12 | ||
DI | rs1037257 | C/T | 0.40 | 1,270 ± 1,017 (151) | 1,375 ± 1,245 (218) | 1,520 ± 1,499 (61) | 0.56 |
rs4969076 | C/G | 0.22 | 1,426 ± 1,247 (234) | 1,255 ± 1,152 (162) | 1,122 ± 1,149 (25) | 0.0050 | |
rs1037260 | T/G | 0.15 | 1,307 ± 1,163 (330) | 1,462 ± 1,321 (92) | 1,445 ± 685 (2) | 0.53 | |
rs11077670 | G/A | 0.10 | 1,415 ± 1,236 (318) | 1,143 ± 1,106 (88) | 1,468 ± 1,524 (6) | 0.0010 | |
rs1868486 | G/T | 0.28 | 1,305 ± 1,049 (199) | 1,436 ± 1,311 (191) | 1,035 ± 1,402 (36) | 0.088 | |
rs714925 | A/G | 0.28 | 1,315 ± 1,032 (196) | 1,430 ± 1,309 (191) | 1,072 ± 1,457 (35) | 0.21 | |
rs998571 | A/G | 0.25 | 1,380 ± 1,158 (214) | 1,353 ± 1,216 (178) | 1,096 ± 1,430 (36) | 0.20 | |
rs7220818 | A/G | 0.41 | 1,443 ± 1,339 (132) | 1,294 ± 1,106 (219) | 1,265 ± 1,098 (72) | 0.63 | |
rs6501603 | T/G | 0.45 | 1,312 ± 1,180 (141) | 1,313 ± 1,161 (203) | 1,578 ± 1,409 (73) | 0.32 | |
rs4969017 | T/C | 0.02 | 1,323 ± 1,200 (417) | 1,540 ± 1,199 (16) | 0.59 | ||
FBG | rs1037257 | C/T | 0.40 | 92.68 ± 9.98 (151) | 93.40 ± 9.01 (231) | 93.93 ± 7.27 (63) | 0.21 |
rs4969076 | C/G | 0.22 | 93.31 ± 9.04 (246) | 92.47 ± 9.20 (172) | 97.52 ± 10.32 (26) | 0.18 | |
rs1037260 | T/G | 0.15 | 93.43 ± 9.46 (350) | 92.38 ± 7.98 (95) | 90.33 ± 7.94 (3) | 0.53 | |
rs11077670 | G/A | 0.10 | 92.75 ± 8.99 (336) | 94.68 ± 9.83 (92) | 97.75 ± 5.40 (6) | 0.099 | |
rs1868486 | G/T | 0.28 | 93.43 ± 9.53 (212) | 92.18 ± 8.51 (199) | 97.41 ± 9.63 (39) | 0.024 | |
rs714925 | A/G | 0.28 | 93.40 ± 9.59 (209) | 92.24 ± 8.46 (199) | 97.87 ± 9.44 (38) | 0.030 | |
rs998571 | A/G | 0.25 | 93.34 ± 9.47 (229) | 92.59 ± 8.55 (185) | 96.25 ± 10.56 (38) | 0.51 | |
rs7220818 | A/G | 0.41 | 93.89 ± 8.88 (143) | 92.88 ± 9.09 (226) | 93.29 ± 10.29 (77) | 0.64 | |
rs6501603 | T/G | 0.45 | 93.02 ± 9.20 (147) | 93.15 ± 9.01 (217) | 93.91 ± 9.27 (76) | 0.60 | |
rs4969017 | T/C | 0.02 | 93.28 ± 9.24 (438) | 92.92 ± 8.70 (18) | 0.92 |
Boldface data indicate P values <0.05.
*Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).
†Major/minor alleles.
‡Test for association among each SNP-trait combination using a series of generalized estimating equations.