Skip to main content
. 2009 Mar 26;58(6):1457–1462. doi: 10.2337/db08-0189

TABLE 3.

Genotypic means for quantitative measures of glucose homeostasis calculated in set 2 of the IRASFS Hispanic-American population

Phenotype SNP Alleles MAF Genotypic means ± SD (n)*
P
1/1 1/2 2/2
SI rs1037257 C/T 0.40 2.35 ± 1.78 (143) 2.08 ± 1.78 (218) 2.34 ± 1.91 (61) 0.60
rs4969076 C/G 0.22 2.31 ± 1.85 (34) 2.15 ± 1.75 (162) 1.82 ± 1.53 (25) 0.15
rs1037260 T/G 0.15 2.19 ± 1.72 (330) 2.28 ± 1.99 (92) 3.19 ± 1.55 (2) 0.83
rs11077670 G/A 0.10 2.29 ± 1.84 (318) 1.96 ± 1.69 (88) 1.81 ± 1.57 (6) 0.039
rs1868486 G/T 0.28 2.24 ± 1.78 (199) 2.23 ± 1.79 (191) 1.68 ± 1.72 (36) 0.038
rs714925 A/G 0.28 2.27 ± 1.81 (196) 2.25 ± 1.79 (191) 1.69 ± 1.75 (35) 0.097
rs998571 A/G 0.25 2.26 ± 1.79 (214) 2.21 ± 1.79 (178) 1.70 ± 1.64 (36) 0.11
rs7220818 A/G 0.41 2.17 ± 1.72 (132) 2.20 ± 1.76 (219) 2.18 ± 1.85 (72) 0.98
rs6501603 T/G 0.45 2.35 ± 1.79 (141) 2.11 ± 1.77 (203) 2.22 ± 1.92 (73) 0.61
rs4969017 T/C 0.02 2.21 ± 1.79 (417) 2.00 ± 1.66 (16) 0.15
AIR rs1037257 C/T 0.40 697 ± 629 (143) 820 ± 739 (218) 841 ± 695 (61) 0.32
rs4969076 C/G 0.22 773 ± 664 (234) 748 ± 692 (162) 776 ± 829 (25) 0.80
rs1037260 T/G 0.15 740 ± 681 (330) 867 ± 712 (92) 455 ± 6 (2) 0.34
rs11077670 G/A 0.10 773 ± 641 (318) 815 ± 886 (88) 831 ± 358 (6) 0.84
rs1868486 G/T 0.28 773 ± 676 (199) 797 ± 727 (191) 618 ± 593 (36) 0.021
rs714925 A/G 0.28 777 ± 671 (196) 794 ± 727 (191) 629 ± 605 (35) 0.089
rs998571 A/G 0.25 786 ± 660 (214) 777 ± 740 (178) 643 ± 596 (36) 0.26
rs7220818 A/G 0.41 757 ± 626 (132) 789 ± 744 (219) 747 ± 646 (72) 0.86
rs6501603 T/G 0.45 709 ± 602 (141) 781 ± 708 (203) 933 ± 837 (73) 0.66
rs4969017 T/C 0.02 744 ± 661 (417) 1,236 ± 1,130 (16) 0.12
DI rs1037257 C/T 0.40 1,270 ± 1,017 (151) 1,375 ± 1,245 (218) 1,520 ± 1,499 (61) 0.56
rs4969076 C/G 0.22 1,426 ± 1,247 (234) 1,255 ± 1,152 (162) 1,122 ± 1,149 (25) 0.0050
rs1037260 T/G 0.15 1,307 ± 1,163 (330) 1,462 ± 1,321 (92) 1,445 ± 685 (2) 0.53
rs11077670 G/A 0.10 1,415 ± 1,236 (318) 1,143 ± 1,106 (88) 1,468 ± 1,524 (6) 0.0010
rs1868486 G/T 0.28 1,305 ± 1,049 (199) 1,436 ± 1,311 (191) 1,035 ± 1,402 (36) 0.088
rs714925 A/G 0.28 1,315 ± 1,032 (196) 1,430 ± 1,309 (191) 1,072 ± 1,457 (35) 0.21
rs998571 A/G 0.25 1,380 ± 1,158 (214) 1,353 ± 1,216 (178) 1,096 ± 1,430 (36) 0.20
rs7220818 A/G 0.41 1,443 ± 1,339 (132) 1,294 ± 1,106 (219) 1,265 ± 1,098 (72) 0.63
rs6501603 T/G 0.45 1,312 ± 1,180 (141) 1,313 ± 1,161 (203) 1,578 ± 1,409 (73) 0.32
rs4969017 T/C 0.02 1,323 ± 1,200 (417) 1,540 ± 1,199 (16) 0.59
FBG rs1037257 C/T 0.40 92.68 ± 9.98 (151) 93.40 ± 9.01 (231) 93.93 ± 7.27 (63) 0.21
rs4969076 C/G 0.22 93.31 ± 9.04 (246) 92.47 ± 9.20 (172) 97.52 ± 10.32 (26) 0.18
rs1037260 T/G 0.15 93.43 ± 9.46 (350) 92.38 ± 7.98 (95) 90.33 ± 7.94 (3) 0.53
rs11077670 G/A 0.10 92.75 ± 8.99 (336) 94.68 ± 9.83 (92) 97.75 ± 5.40 (6) 0.099
rs1868486 G/T 0.28 93.43 ± 9.53 (212) 92.18 ± 8.51 (199) 97.41 ± 9.63 (39) 0.024
rs714925 A/G 0.28 93.40 ± 9.59 (209) 92.24 ± 8.46 (199) 97.87 ± 9.44 (38) 0.030
rs998571 A/G 0.25 93.34 ± 9.47 (229) 92.59 ± 8.55 (185) 96.25 ± 10.56 (38) 0.51
rs7220818 A/G 0.41 93.89 ± 8.88 (143) 92.88 ± 9.09 (226) 93.29 ± 10.29 (77) 0.64
rs6501603 T/G 0.45 93.02 ± 9.20 (147) 93.15 ± 9.01 (217) 93.91 ± 9.27 (76) 0.60
rs4969017 T/C 0.02 93.28 ± 9.24 (438) 92.92 ± 8.70 (18) 0.92

Boldface data indicate P values <0.05.

*Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).

†Major/minor alleles.

‡Test for association among each SNP-trait combination using a series of generalized estimating equations.