TABLE 4.
Genotypic means for quantitative measures of glucose homeostasis calculated in the combined IRASFS Hispanic-American population
| Phenotype | SNP | Alleles† | MAF | Genotypic means ± SD (n)* |
P‡ | P§ | ||
|---|---|---|---|---|---|---|---|---|
| 1/1 | 1/2 | 2/2 | ||||||
| SI | rs1037257 | C/T | 0.38 | 2.36 ± 2.04 (350) | 2.01 ± 1.68 (498) | 2.22 ± 2.057 (146) | 0.60 | 0.16 |
| rs4969076 | C/G | 0.22 | 2.21 ± 1.95 (549) | 2.09 ± 1.72 (360) | 2.05 ± 1.93 (55) | 0.43 | 0.41 | |
| rs1037260 | T/G | 0.14 | 2.13 ± 1.83 (800) | 2.26 ± 2.02 (186) | 2.47 ± 1.63 (7) | 0.83 | 0.75 | |
| rs11077670 | G/A | 0.12 | 2.18 ± 1.92 (716) | 2.11 ± 1.80 (227) | 1.92 ± 1.84 (14) | 0.24 | 0.62 | |
| rs1868486 | G/T | 0.29 | 2.23 ± 1.94 (453) | 2.16 ± 1.86 (423) | 1.76 ± 1.61 (109) | 0.000071 | 0.0025 | |
| rs714925 | A/G | 0.29 | 2.23 ± 1.94 (440) | 2.15 ± 1.85 (434) | 1.74 ± 1.55 (106) | 0.0010 | 0.0030 | |
| rs998571 | A/G | 0.27 | 2.25 ± 1.91 (475) | 2.17 ± 1.89 (397) | 1.71 ± 1.50 (109) | 0.00018 | 0.0024 | |
| rs7220818 | A/G | 0.39 | 2.02 ± 1.69 (348) | 2.15 ± 1.86 (487) | 2.48 ± 2.14 (163) | 0.60 | 0.16 | |
| rs6501603 | T/G | 0.47 | 2.31 ± 1.99 (293) | 2.07 ± 1.82 (479) | 2.17 ± 1.79 (201) | 0.29 | 0.13 | |
| rs4969017 | T/C | 0.03 | 2.17 ± 1.89 (946) | 1.98 ± 1.37 (36) | 1.01 ± 0.00 (1) | 0.83 | 0.94 | |
| AIR | rs1037257 | C/T | 0.38 | 706 ± 579 (350) | 777 ± 675 (498) | 844 ± 708 (146) | 0.32 | 0.16 |
| rs4969076 | C/G | 0.22 | 781 ± 640 (549) | 721 ± 635 (360) | 800 ± 719 (55) | 0.48 | 0.66 | |
| rs1037260 | T/G | 0.14 | 754 ± 659 (800) | 814 ± 643 (186) | 496 ± 147 (7) | 0.50 | 0.78 | |
| rs11077670 | G/A | 0.12 | 772 ± 629 (716) | 730 ± 725 (227) | 882 ± 586 (14) | 0.37 | 0.55 | |
| rs1868486 | G/T | 0.29 | 747 ± 599 (453) | 799 ± 715 (423) | 710 ± 664 (109) | 0.43 | 0.58 | |
| rs714925 | A/G | 0.29 | 750 ± 598 (440) | 798 ± 711 (434) | 711 ± 675 (106) | 0.48 | 0.56 | |
| rs998571 | A/G | 0.27 | 751 ± 590 (475) | 796 ± 730 (397) | 731 ± 667 (109) | 0.99 | 0.99 | |
| rs7220818 | A/G | 0.39 | 776 ± 636 (348) | 762 ± 687 (487) | 741 ± 601 (163) | 0.90 | 0.96 | |
| rs6501603 | T/G | 0.47 | 735 ± 592 (293) | 771 ± 674 (479) | 786 ± 692 (201) | 0.46 | 0.47 | |
| rs4969017 | T/C | 0.03 | 756 ± 641 (946) | 871 ± 839 (36) | 195 ± 0 (1) | 0.75 | 0.25 | |
| DI | rs1037257 | C/T | 0.38 | 1,332 ± 1,179 (350) | 1,290 ± 1,221 (498) | 1,444 ± 1,408 (146) | 0.56 | 0.92 |
| rs4969076 | C/G | 0.22 | 1,409 ± 1,344 (549) | 1,186 ± 1,018 (360) | 1,357 ± 1,380 (55) | 0.051 | 0.036 | |
| rs1037260 | T/G | 0.14 | 1,287 ± 1,201 (800) | 1,474 ± 1,362 (186) | 1,275 ± 910 (7) | 0.82 | 0.90 | |
| rs11077670 | G/A | 0.12 | 1,376 ± 1,277 (716) | 1,137 ± 1,056 (227) | 1,575 ± 1,615 (14) | 0.00025 | 0.015 | |
| rs1868486 | G/T | 0.29 | 1,335 ± 1,225 (453) | 1,385 ± 1,295 (423) | 1,030 ± 1,107 (109) | 0.00037 | 0.0075 | |
| rs714925 | A/G | 0.29 | 1,333 ± 1,209 (440) | 1,373 ± 1,250 (434) | 1,009 ± 1,076 (106) | 0.0010 | 0.0061 | |
| rs998571 | A/G | 0.27 | 1,365 ± 1,233 (475) | 1,373 ± 1,299 (397) | 1,028 ± 1,064 (109) | 0.0030 | 0.027 | |
| rs7220818 | A/G | 0.39 | 1,326 ± 1,242 (348) | 1,277 ± 1,203 (487) | 1,450 ± 1,285 (163) | 0.070 | 0.14 | |
| rs6501603 | T/G | 0.47 | 1,391 ± 1,320 (293) | 1,265 ± 1,169 (479) | 1,355 ± 1,177 (201) | 0.30 | 0.24 | |
| rs4969017 | T/C | 0.03 | 1,326 ± 1,252 (946) | 1,295 ± 1,087 (36) | 197 ± 0 (1) | 0.66 | 0.47 | |
| FBG | rs1037257 | C/T | 0.38 | 93.03 ± 9.60 (371) | 93.65 ± 9.72 (529) | 93.31 ± 8.74 (151) | 0.21 | 0.87 |
| rs4969076 | C/G | 0.22 | 93.46 ± 9.75 (589) | 93.13 ± 9.10 (374) | 94.01 ± 9.65 (58) | 0.47 | 0.54 | |
| rs1037260 | T/G | 0.14 | 93.33 ± 9.51 (848) | 93.38 ± 9.37 (194) | 92.95 ± 10.49 (10) | 0.91 | 0.74 | |
| rs11077670 | G/A | 0.12 | 93.21 ± 9.56 (763) | 93.89 ± 9.63 (236) | 96.93 ± 8.97 (14) | 0.056 | 0.11 | |
| rs1868486 | G/T | 0.29 | 92.90 ± 9.63 (484) | 93.52 ± 9.44 (442) | 95.31 ± 9.52 (116) | 0.010 | 0.083 | |
| rs714925 | A/G | 0.29 | 92.81 ± 9.56 (473) | 93.49 ± 9.41 (452) | 95.34 ± 9.66 (113) | 0.010 | 0.045 | |
| rs998571 | A/G | 0.27 | 92.83 ± 9.48 (509) | 93.51 ± 9.57 (415) | 94.90 ± 9.75 (115) | 0.010 | 0.079 | |
| rs7220818 | A/G | 0.39 | 93.87 ± 11.96 (365) | 93.44 ± 1097 (513) | 91.96 ± 9.74 (178) | 0.10 | 0.25 | |
| rs6501603 | T/G | 0.47 | 93.17 ± 9.49 (313) | 93.71 ± 9.82 (510) | 93.03 ± 9.02 (208) | 0.76 | 0.72 | |
| rs4969017 | T/C | 0.03 | 93.40 ± 9.49 (1000) | 91.64 ± 9.21 (40) | 93.00 ± 0.00 (1) | 0.41 | 0.81 | |
Boldface data indicate P values <0.05.
*Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).
†Major/minor alleles.
‡Test for association among each SNP-trait combination using a series of generalized estimating equations.
§Meta-analysis P value computed by sequential oligogenic linkage analysis with the modeling of set 1 or set 2 affiliation as a random effect in a variance component–measured genotype model.