TABLE 1.
Partial pancreatectomy and high-dose exendin-4 treatment
| Age (months) | Body weight (g) in The Jackson Laboratory cohort |
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|---|---|---|---|---|---|---|---|---|
| Sham operated (control) |
Partial pancreatectomy |
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| Initial | Final | Change | Initial | Final | Change | P | ||
| 2 | 30.9 ± 1.1 | 25.6 ± 1.4 | 5.3 ± 0.5 | 30.2 ± 0.9 | 26.0 ± 0.8 | 4.2 ± 0.2 | 0.387 | |
| 8 | 38.1 ± 1.1 | 33.0 ± 0.4 | 5.1 ± 0.7 | 36.9 ± 1.4 | 31.9 ± 1.5 | 5.0 ± 0.4 | 0.307 | |
| 12 | 42.2 ± 2.5 | 35.7 ± 1.7 | 6.5 ± 1.5 | 41.7 ± 2.5 | 33.3 ± 0.9 | 8.0 ± 2.4 | 0.914 | |
| 14 | 45.3 ± 2.6 | 37.1 ± 1.7 | 8.2 ± 1.1 | 36.4 ± 6.6 | 28.2 ± 4.7 | 8.1 ± 2.4 | 0.749 | |
| 19 | 48.9 ± 2.4 | 44.7 ± 2.2 | 4.1 ± 0.9 | 46.9 ± 4.0 | 40.6 ± 3.5 | 4.4 ± 0.7 | 0.923 | |
| Age (months) | Body glucose (mg/dl) in The Jackson Laboratory cohort |
|||||||
|---|---|---|---|---|---|---|---|---|
| Sham operated (control) |
Partial pancreatectomy |
|||||||
| Initial | Final | Average | Initial | Final | P | Average | P | |
| 2 | 135 ± 10 | 122 ± 9 | 121 ± 9 | 135 ± 11 | 145 ± 10 | 0.117 | 143 ± 5 | 0.063 |
| 8 | 121 ± 7 | 120 ± 11 | 114 ± 7 | 137 ± 7 | 122 ± 9 | 0.857 | 123 ± 4 | 0.307 |
| 12 | 136 ± 7 | 134 ± 13 | 131 ± 4 | 132 ± 9 | 137 ± 9 | 0.838 | 131 ± 7 | 0.914 |
| 14 | 139 ± 9 | 131 ± 6 | 124 ± 6 | 131 ± 6 | 108 ± 8 | 0.794 | 121 ± 4 | 0.749 |
| 19 | 115 ± 8 | 132 ± 6 | 125 ± 6 | 109 ± 7 | 139 ± 9 | 0.783 | 125 ± 3 | 0.923 |
| Age (months) | Body weight (g) in the Taconic Farms cohort |
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|---|---|---|---|---|---|---|---|---|
| Sham operated (control) |
Partial pancreatectomy |
|||||||
| Initial | Final | Change | Initial | Final | Change | P | ||
| 2 | 31.7 ± 1.1 | 30.6 ± 0.9 | 1.1 ± 0.9 | 29.7 ± 0.4 | 28.4 ± 1.1 | 1.3 ± 1.4 | 0.928 | |
| 19 | 42.4 ± 5.1 | 39.1 ± 5.7 | 3.3 ± 1.1 | 42.0 ± 2.7 | 36.8 ± 1.4 | 5.2 ± 1.7 | 0.401 | |
| Age (months) | Body glucose (mg/dl) in the Taconic Farms cohort |
|||||||
|---|---|---|---|---|---|---|---|---|
| Sham operated (control) |
Partial pancreatectomy |
|||||||
| Initial | Final | Average | Initial | Final | P | Average | P | |
| 2 | 134 ± 12 | 126 ± 12 | 128 ± 8 | 127 ± 7 | 132 ± 11 | 0.117 | 131 ± 7 | 0.570 |
| 19 | 94 ± 9 | 100 ± 11 | 98 ± 8 | 86 ± 9 | 103 ± 11 | 0.783 | 92 ± 5 | 0.605 |
Data are means ± SEM for four to seven mice per group except the 19-month-old partial pancreatectomy cohort, which consisted of only three mice. Body weight of mice before and 2 weeks after a sham operation (top left) or partial pancreatectomy (top right). Random-fed blood glucose values for 2 weeks following sham operation or partial pancreatectomy, expressed as average values (middle left) or area under the curve (middle right).