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. 2009 Mar 5;58(6):1365–1372. doi: 10.2337/db08-1198

TABLE 2.

β-Cell morphometry

Age (months)
2 8 12 14 19
Pancreatic weight (mg)
    Sham operated (control) 253 ± 13 301 ± 19 ND 331 ± 6 386 ± 24
    Partial pancreatectomy
Resected (splenic) 127 ± 5 169 ± 15 ND 184 ± 3 187 ± 9
Remaining (duodenal) 108 ± 32 113 ± 18 ND 204 ± 6 212 ± 27
β-Cell area (%)
    Sham operated (control) 0.61 ± 0.09 0.85 ± 0.17 ND 1.27 ± 0.28 2.04 ± 0.36
    Partial pancreatectomy
Resected (splenic) 0.72 ± 0.11 1.05 ± 0.13 ND 1.90 ± 0.61 2.60 ± 0.61
Remaining (duodenal) 0.60 ± 0.04 0.79 ± 0.12 ND 1.28 ± 0.20 2.07 ± 0.55
β-Cell mass (mg)
    Sham operated (control)
Whole pancreas 1.57 ± 0.26 2.46 ± 0.41 ND 4.15 ± 0.89 7.89 ± 1.59
    Partial pancreatectomy
Resected (splenic) 0.98 ± 0.14 1.81 ± 0.31 ND 3.48 ± 1.12 4.76 ± 1.07
Remaining (duodenal) 0.78 ± 0.23 0.93 ± 0.23 ND 2.59 ± 0.36 4.72 ± 1.75
Acinar proliferation (% BrdU/total)
    Sham operated (control) 0.72 ± 0.08 0.57 ± 0.07 ND 0.41 ± 0.07 0.53 ± 0.11
    Partial pancreatectomy 1.47 ± 0.28 1.64 ± 0.14 ND 1.62 ± 0.24 1.07 ± 0.1
    P 0.04 0.0002 ND 0.001 0.02

Data are means ± SEM for four to seven mice per group except the 19-month-old partial pancreatectomy cohort, which consisted of only three mice. Data show pancreatic weight of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as milligrams; β-cell area of sham-operated, resected (splenic portion), or remaining pancreas (duodenal portion) following partial pancreatectomy, expressed as percent total pancreas; β-cell mass of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as percent total pancreas; and acinar proliferation of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as percent total pancreas. ND, not determined.

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