TABLE 3.

HRs for the development of severe nephropathy during 16–22 years of follow-up in the DCCT/EDIC study for SNPs associated with diabetic nephropathy in GoKinD

Locus						P values and HRs in DCCT/EDIC collection severe nephropathy
SNP	Chromosome	Position (Mb)	Nearest gene(s)	Risk allele*	Frequency of risk allele	P (one-sided)†	HR
rs39075	7p	29.2	CPVL/CHN2	G	0.60	NS	0.85
rs1888746‡	9q	85.3	FRMD3	C	0.70	0.02	1.33
rs13289150§	9q	85.4	FRMD3	A	0.62	0.05	1.23
rs451041	11p	3.0	CARS	A	0.51	0.01	1.32
rs1041466	13q	109.0	No gene	G	0.47	0.11	1.22
rs1411766	13q	109.1	No gene	A	0.36	0.11	1.17
rs6492208	13q	109.1	No gene	T	0.61	NS	0.90
rs7989848	13q	109.1	No gene	A	0.53	NS	0.93

Data are from multivariate Cox proportional hazard analysis of time to onset of severe nephropathy. As of 2005, the number of severe nephropathy cases was 132 (vs. 1,172 censored). Chromosomal locations, SNP positions, and gene annotations are in reference to NCBI Build 36.1.

*The risk alleles that are presented are in reference to those identified in the GoKinD collection;

†one-sided P values (consistent with the current “best practices” for replication in GWA scans) (20–22) are used to test for the same direction of effect as in the GoKinD collection;

‡rs1888746 was genotyped on an Illumina array in DCCT/EDIC and is in complete linkage disequilibrium (r² = 1.0) with rs1888747 (genotyped using a Taqman assay in GoKinD);

§rs13289150 was genotyped on an Illumina array in DCCT/EDIC and is in complete linkage disequilibrium (r² = 1.0) with rs10868025 (genotyped on an Affymetrix array in GoKinD).