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. 2009 Mar 10;58(6):1342–1349. doi: 10.2337/db08-0958

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© 2009 by the American Diabetes Association.

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FIG. 5. — GIP receptors are present on human and mouse islets. Immunofluorescent images show coexpression of insulin with GIPR and coexpression of glucagon with GIPR in human (A) and in mouse (B) islets. C: GIP receptors are present on αTC1 cells as shown on immunoflurescent images. Stimulation of αTC1 cells with GIP led to increased intracellular cAMP levels (D) and glucagon secretion (E) in a concentration-dependent manner. F: In αTC1 cells, GIP-mediated glucagon secretion was diminished in the presence of GIP (3–42), a GIP receptor antagonist. □, vehicle; ■, 1 μmol/l GIP. (A high-quality digital representation of this figure is available in the online issue.)