TABLE 2.
Associations with DM/IGT and AUC for glucose and insulin in the total population
| Gene variant | Major/minor allele | OR1 diabetes/IGT (95% CI) | OR2 diabetes/IGT (95% CI) | β1 AUC glucose | β2 AUC glucose | β1 AUC insulin | β2 AUC insulin |
|---|---|---|---|---|---|---|---|
| CDKAL1 rs7754840 | G/C | 1.11 (0.87–1.42) | 1.16 (0.90–1.49) | 0.04 (−3.3 to 3.4) | 0.7 (−2.6 to 4.0) | −8.2 (−16.1 to −0.41) | −6.0 (−13.3 to 1.3) |
| CDKN2A/B rs10811661 | T/C | 1.08 (0.81–1.44) | 1.03 (0.76–1.39) | −0.004 (−4.0 to 4.0) | −0.4 (−4.2 to 3.5) | −0.22 (−9.4 to 8.9) | −1.4 (−9.9 to 7.1) |
| HHEX rs1111875 | C/T | 1.09 (0.86–1.36) | 0.99 (0.79–1.27) | −2.1 (−5.2 to 1.0) | −2.7 (−5.8 to 0.3) | 2.43 (−4.8 to 9.62) | 0.1 (−6.7 to 6.8) |
| IGF2BP2 rs4402960 | G/T | 1.43 (1.11–1.85) | 1.42 (1.09–1.84) | 3.6 (0.1–7.1) | 3.2 (−0.2 to 6.5) | 3.16 (−4.9 to 11.2) | 1.66 (−5.9 to 9.2) |
| KCNJ11 rs5219 | AG (341) | 0.97 (0.76–1.23) | 0.99 (0.77–1.27) | −1.4 (−4.7 to 1.8) | −1.4 (−4.5 to 1.8) | 2.46 (−5.1 to 10.0) | 2.9 (−4.1 to 9.9) |
| SLC30A8 rs13266634 | C/T (299) | 0.88 (0.68–1.13) | 0.91 (0.70–1.18) | 0.3 (−3.1 to 3.8) | 0.6 (−2.7 to 3.9) | 4.26 (−3.7 to 12.2) | 4.8 (−2.6 to 12.1) |
| TCF7L2 rs7903146 | C/T (316) | 1.39 (1.08–1.79) | 1.37 (1.06–1.78) | 4.5 (1.0–8.1) | 4.6 (1.2–8.0) | −5.5 (−13.5 to 2.52) | −5.3 (−12.9 to 2.1) |
OR1 and β1: adjusted for sex. OR2 and β2: adjusted for sex and BMI.