Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2009 Feb;53(2):121–131. doi: 10.1097/FJC.0b013e31819715c4

Figure 4.

Figure 4

Effects of BAY 41-2272 on nuclear cyclin expression in VSM after 48 hours incubation. A: Western blot showing protein expression for the G1 cyclins A, D1, and E. B-D: Densitometry (normalized to nuclear GAPDH) reveals that BAY (0.001-10 μM) elevates expression of cyclins A (∼80%) and D1 (∼50%) and significantly increases cyclin E (∼200%; p = .015). Concomitant staining for APE/Ref1 verified nuclear localization of all samples (data not shown). Results are mean ± SEM, and n = 5 experiments/group. Post-hoc results: *statistically significant versus DMSO controls with p < .05.