Table 2.

Associations of age at natural menopause and risk of incident ischemic stroke among women in the Framingham Heart Study (n= 1,430).

Age at Natural Menopause	Number of Participants	Number of Ischemic Strokes	Age-adjusted			Multivariable-adjusted*
			HR	95% CI	P	HR	95% CI	P
<42	56	13	1.00			1.00
42-54	1,299	213	0.57	0.33-1.01	0.05	0.50	0.29-0.89	0.02
≥55	75	8	0.33	0.14-0.79	0.01	0.31	0.13-0.76	0.01
Never Smokers at Age 60
<42	30	9	1.00			1.00
42-54	605	96	0.38	0.19-0.76	0.01	0.39	0.20-0.78	0.01
≥55	40	6	0.34	0.12-0.96	0.04	0.40	0.14-1.12	0.08
Never Estrogen Users at Age 60
<42	51	12	1.00			1.00
42-54	1158	193	0.54	0.30-0.97	0.04	0.48	0.27-0.87	0.02
≥55	63	7	0.31	0.12-0.79	0.01	0.30	0.12-0.77	0.01

HR = hazard ratio, CI = confidence interval

^*Adjusted for age, systolic blood pressure, atrial fibrillation, diabetes, current smoking, cardiovascular disease, and estrogen use.