Table 3.
Associations of bone mineral density measured at three sites and risk of incident ischemic stroke among women in the Framingham Heart Study (n=654).
Quintile of BMD | Number of Participants | Number of Ischemic Strokes | Age-adjusted | Multivariable-adjusted* | ||||
---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |||
Femoral neck | ||||||||
Q1 | 122 | 18 | 1.37 | 0.69-2.73 | 0.36 | 1.33 | 0.66-2.68 | 0.42 |
Q2 | 124 | 18 | 1.25 | 0.63-2.38 | 0.53 | 1.30 | 0.65-2.59 | 0.45 |
Q3 | 126 | 15 | 1.00 | 1.00 | ||||
Q4 | 124 | 17 | 1.18 | 0.59-2.36 | 0.65 | 0.92 | 0.45-1.88 | 0.81 |
Q5 | 124 | 24 | 1.72 | 0.90-3.29 | 0.10 | 1.41 | 0.72-2.76 | 0.32 |
Trochanter | ||||||||
Q1 | 125 | 25 | 2.17 | 1.07-4.38 | 0.03 | 2.36 | 1.15-4.83 | 0.02 |
Q2 | 127 | 19 | 1.13 | 0.51-2.52 | 0.76 | 1.07 | 0.48-2.41 | 0.87 |
Q3 | 128 | 9 | 1.00 | 1.00 | ||||
Q4 | 131 | 18 | 1.90 | 0.93-3.86 | 0.08 | 1.77 | 0.86-3.64 | 0.12 |
Q5 | 126 | 24 | 2.38 | 1.19-4.77 | 0.01 | 1.94 | 0.94-3.95 | 0.07 |
Radius | ||||||||
Q1 | 122 | 22 | 3.18 | 1.48-6.82 | 0.00 | 2.92 | 1.55-6.34 | 0.01 |
Q2 | 123 | 12 | 2.10 | 0.95-4.65 | 0.07 | 1.94 | 0.87-4.32 | 0.11 |
Q3 | 125 | 12 | 1.00 | 1.00 | ||||
Q4 | 123 | 21 | 2.07 | 0.93-4.60 | 0.08 | 1.68 | 0.74-3.80 | 0.21 |
Q5 | 123 | 24 | 2.92 | 1.36-6.28 | 0.01 | 2.43 | 1.12-5.30 | 0.03 |
Q = quintile, HR = hazard ratio, CI = confidence interval, BMD = bone mineral density
Adjusted for age, systolic blood pressure, atrial fibrillation, diabetes, current smoking, cardiovascular disease, estrogen use, and body mass index.