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. 2009 Apr 1;29(13):4096–4108. doi: 10.1523/JNEUROSCI.3623-08.2009

Figure 8.

Figure 8.

Bath application of MCP-1 increases excitatory synaptic transmission and AMPA- and NMDA-induced currents. A, Patch-clamp recording of sEPSCs shows increase in the frequency and amplitude of sEPSC after perfusion of MCP-1 (100 ng/ml, 2 min). Aa and Ab are enlarged recording before and after MCP-1 treatment, respectively. B, C, Ratio of the frequency and amplitude of sEPSCs after MCP-1 treatment. **p < 0.01 versus pretreatment baseline. D–G, Patch-clamp recording demonstrates increase in AMPA-induced currents (D, E) and NMDA-induced currents (F, G) after MCP-1 treatment (100 ng/ml, 2 min). The amplitude of AMPA- and NMDA-induced currents is shown in E and G, respectively. *p < 0.05 versus pretreatment baseline. Inside each column, the number of total recorded neurons and number of responding neurons are indicated (B, C, E, G).