Table 3.
Mean net change in LDL cholesterol, HDL cholesterol, and triglycerides after vitamin C supplementation
| Source and Year (Reference) | Sample Size | Net Lipid Changea (95% CI) | P Valueb |
|---|---|---|---|
| LDL Cholesterol | |||
| Horsey et al 198116 | 25 | −13.9 (−32.3, 4.5) | NS |
| Wahlberg and Walldius 198217 | 18 | 1.2 (−31.0, 33.3) | NS |
| Salonen et al 199120 | 78 | 3.9 (−6.3, 14.0) | NS |
| Cerna et al 199221 | 134 | −17.8 (−29.5, −6.0) | .004 |
| Paolisso et al 199522 | 80 | −57.9 (−91.4, −24.4) | .001 |
| Gokce et al 199923 | 46 | −1.0 (−13.2, 11.2) | NS |
| Fotherby et al 200024 | 80 | −3.9 (−14.0, 6.3) | NS |
| Singhal et al 200125 | 63 | −1.9 (−14.0, 10.2) | NS |
| Vinson and Jang 200126 | 18 | −34.0 (−67.3, −0.7) | NS |
| Rezaian et al 200227 | 60 | −26.5 (−44.9, −8.0) | .007 |
| Shidfar et al 200328 | 36 | −21.7 (−40.5, −2.9) | .030 |
| HDL Cholesterol | |||
| Horsey et al 198116 | 25 | 7.3 (−0.7, 15.4) | NS |
| Wahlberg and Walldius 198217 | 18 | −1.5 (−7.8, 4.7) | NS |
| Aro et al 198819 | 54 | −1.5 (−5.0, 1.9) | NS |
| Salonen et al 199120 | 78 | −1.9 (−5.8, 1.9) | NS |
| Cerna et al 199221 | 135 | 2.3 (−1.1, 5.8) | NS |
| Paolisso et al 199522 | 80 | 3.9 (−3.7, 11.4) | NS |
| Gokce et al 199923 | 46 | −4.0 (−8.4, 0.4) | NS |
| Fotherby et al 200024 | 80 | 1.2 (−3.1, 5.4) | NS |
| Singhal et al 200125 | 63 | 0.3 (−3.4, 4.0) | NS |
| Vinson and Jang 200126 | 18 | −0.8 (−8.4, 6.8) | NS |
| Rezaian et al 200227 | 60 | 11.7 (8.0, 15.3) | .000 |
| Shidfar et al 200328 | 36 | −1.4 (−4.9, 2.1) | NS |
| Triglycerides | |||
| Wahlberg and Walldius 198217 | 18 | 59.4 (−62.3, 181.0) | NS |
| Bishop et al 198518 | 50 | −43.4 (−99.9, 13.1) | NS |
| Bishop et al 198518 | 50 | 4.4 (−68.5, 77.4) | NS |
| Cerna et al 199221 | 138 | 0.9 (−44.7, 46.5) | NS |
| Paolisso et al 199522 | 80 | −44.3 (−72.1, −16.5) | .003 |
| Gokce et al 199923 | 46 | 27.0 (−28.5, 82.5) | NS |
| Singhal et al 200125 | 63 | −33.5 (−68.0, 1.0) | NS |
| Vinson and Jang 200126 | 18 | 18.6 (−32.2, 69.4) | NS |
| Rezaian et al 200227 | 60 | −11.1 (−37.9, 15.8) | NS |
| Shidfar et al 200328 | 36 | −52.7 (−103.3, −2.1) | .049 |
NS, Not significant.
a
For parallel trials, the net change is (intervention final lipid − baseline lipid) − (control final lipid − baseline lipid). For crossover trials, the net change is intervention final lipid − control final lipid.
b
The P value was calculated by the author.