TABLE 4.

Association of exposure to the Dutch famine at any period during gestation with the prevalence of fasting lipid abnormalities among men and women examined between 2003 and 2005¹

	Famine-exposed men (n = 158)			Famine-exposed women (n = 186)
	Odds ratio	95% CI	P	Odds ratio	95% CI	P
Total cholesterol ≥ 6.216 mmol/L (240 mg/dL)	0.69	0.39, 1.21	0.20	1.38	0.91, 2.09	0.13
HDL cholesterol < 1.036 mmol/L (40 mg/dL)	0.92	0.50, 1.70	0.79	0.71	0.20, 2.46	0.58
LDL cholesterol > 4.138 mmol/L (160 mg/dL)	0.78	0.46, 1.29	0.33	1.76	1.03, 3.02	0.04
Triglycerides ≥ 1.69 mmol/L (150 mg/dL)	1.12	0.69, 1.83	0.64	1.90	1.14, 3.15	0.01
Use of cholesterol-lowering medication	0.79	0.44, 1.42	0.44	1.75	0.98, 3.12	0.06
Dyslipidemia (ratio of total cholesterol to HDL cholesterol > 5.0 or use of cholesterol-lowering medication)	0.83	0.50, 1.39	0.49	1.44	0.82, 2.52	0.20

¹Values represent odds ratios relative to sex-specific unexposed control subjects (294 hospital controls: 158 men and 136 women; 308 sibling controls: 177 men and 131 women) obtained by logistic regression with adjustment for age (linear and quadratic terms), cholesterol medication, and clustering within sibships. Tests for heterogeneity by sex as obtained from coefficients from interaction terms in regression models were as follows: total cholesterol (P = 0.01); HDL cholesterol (P = 0.87); LDL cholesterol (P = 0.01); triglycerides (P = 0.03); use of cholesterol-lowering medication (P = 0.04), and dyslipidemia (P = 0.06).