Figure 2.

Blockade of URB597-, WY14643-, and THC-induced effects on memory acquisition. Data are expressed as mean latency (sec) ± SEM to enter the dark compartment during the retention test. Blockade of PPAR-α by MK886 (1 mg/kg) reversed the enhancement of memory acquisition by URB597 (0.1 mg/kg; A) and WY14643 (40 mg/kg; B). Blockade of CB₁ reversed the enhancement produced by URB597 and also reversed the deficits induced by THC (3 mg/kg) when given before the learning trial (C) or before the retention test (D). From left to right, Ns for the bars in A were: 10, 10, 8, 8, 8, and 10; in B: 10, 7, 8, and 8; in C: 10, 7, 8, and 10; and in D: 9, 8, 9, and 9. (*) P < 0.05 compared with vehicle control (VEH), paired comparisons performed with Tukey procedure.