Figure 3.

Effects of drugs on open-field behavior. Data are expressed as mean ± SEM. (A) Distance traveled, (B) average speed, (C) time spent within 5 cm of a wall (thigmotaxis), (D) center-zone entries, (E) vertical counts, (F) stereotypy counts, (G) jump counts, and (H) ambulatory episodes. Although URB597 (0.1 mg/kg) produced a small but significant increase in jumping (G) (P < 0.05) and WY14643 (20 mg/kg) produced a marginal decrease in distance traveled (A) (P < 0.056) compared with vehicle control (VEH), none of the other treatments had a significant effect on any of these measures of general activity (A,B,E,H) or anxiety-related behavior (C,D). From left to right, Ns for the bars in all panels were: 7, 7, 7, 7, 7, 7, 13, 6, 6, and 7. All paired comparisons performed with Tukey procedure.