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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: J Surg Res. 2008 Jun 2;152(2):311–318. doi: 10.1016/j.jss.2008.05.001

Figure 5. Putative model of norepinephrine-mediated alterations in 120-hour wound neutrophil phagocytosis.

Figure 5

Based on the results of experiments including stimulation of neutrophils with norepinephrine and pharmacologic blockade of both α- and β-adrenergic subtypes, as well as the PKA signaling cascade, a putative model of norepinephrine-mediated modulation of wound neutrophil phagocytic efficiency is proposed. At a pharmacologic dose of NE, both adrenergic receptor subtypes appear to be involved in the reduction of wound neutrophil phagocytic efficiency, and the intracellular effects of NE treatment appear to be mediated via PKA. Future experiments to determine the mechanistic changes downstream of PKA that lead to alterations in phagocytic efficiency are warranted.