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. 2009 Mar 12;28(9):1308–1318. doi: 10.1038/emboj.2009.57

Figure 5.

Figure 5

Cold-sensitive behaviour of wild-type, TRAAK−/− and TREK-1−/−-TRAAK−/− mice in normal and CCI neurophatic conditions. (A) Nocifensive cold-plate test showing reduced latency of TREK-1−/−-TRAAK−/− mice. The temperature of the plate is indicated in the graph. (B) Thermal discrimination test with two temperature plates. The temperature of one of the plates was maintained at 30°C and the temperature of the second plate was set as indicated. The time indicated is the fraction of time spent by the mice on the 30°C plate measured over 3 min. (C) Cold allodynia of CCI neuropathic wild-type, TRAAK−/− and TREK-1−/−-TRAAK−/− mice measured as the total time of lifting of the paw over 3 min when mice were placed on a cold plate at 15 and 20°C. Values are mean±s.e.m. Stars mark significant differences, with one star for P<0.05 and two stars for P<0.01; two-way ANOVA with Tukey's post-test.