Figure 2.

Intra-dmPFC BDNF suppressed cocaine-primed reinstatement. Left, The average number of lever presses during the last 3 d of self-administration (before BDNF infusion) was not different between groups (N = 9–10 per group). Intra-PFC BDNF infusion at the end of self-administration suppressed active lever presses on the first day of extinction (left, middle) but did not affect the remainder of extinction training (right, middle). Intra-dmPFC BDNF suppressed cocaine prime-induced reinstatement (right, N = 6–8 rats per group; only rats with complete microdialysis data were included). *p < 0.05.