Fig. 2.

Knockdown of α₅-integrin in HeLa cells reduces EboV GP-mediated infection. HeLa cells transfected with a nontargeting control siRNA oligonucleotide (Con) or siRNA oligonucleotides targeting α₅- or β₁-integrin were biotinylated and lysed for avidin precipitation and immunoblotting (A) or infected with VSV-GPΔ or VSV-G (B). (A) Representative immunoblots, presented as in Fig. 1, with densitometry values presented below showing the amount of protein, normalized for GAPDH loading, relative to the control siRNA-treated cells. (B) Data shown are the averages from 5 experiments. Error bars indicate SEM. *, P ≤ 0.0008 relative to control siRNA-treated cells.