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. 2009 Apr 29;106(19):8043–8048. doi: 10.1073/pnas.0900358106

Fig. 3.

Fig. 3.

Inhibition/ablation of Oct3 protected against MPTP neurotoxicity. Oct3−/− mice and their wild-type littermates Oct3+/+ (A–J), and C57BL/6 mice (K and L) infused s.c. with either saline or varying doses of D22, were injected with MPTP or saline. The loss of TH-positive neurons in the nigra (A–D and I) was completely prevented in the Oct3−/− mice (I) and by D22 (K, in a dose-dependent manner). Damage to the striatal density of TH-positive fibers (E–H, J, and L) was also attenuated in these animals. (I and J) (a) P < 0.01 compared to the Oct3+/+ saline group; (b) P < 0.01 compared to the Oct3−/− saline group; (c) P < 0.05 compared to the Oct3+/+ MPTP group, analyzed by 2-way ANOVA with treatments crossed with genotypes (panel I: genotype: F1,15 = 8.70, P = 0.01; treatment: F1,15 = 2.99, P = 0.10; panel J genotype: F1,15: = 6.60, P = 0.021; treatment: F1,15 = 67.07, P < 0.001) followed by the Newman-Keuls posthoc test. (K and L) (a) P < 0.01 compared to the control saline group; (b) P < 0.05 compared to the MPTP group without D22, analyzed by 1-way ANOVA followed by the Newman-Keuls post hoc test (panel K: F4,13 = 30.13, P < 0.001; panel L: F4,14 = 55.37, P < 0.001). Data represent mean ± SEM from 3–5 animals per group.