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Inhibition of tumor cell growth in vivo. (A) Hdac1flox/flox Hdac2flox/flox cells were incubated for 8 h with either GFP- or Cre-expressing virus and injected s.c. into nude mice. Tumor growth is shown 3 weeks after injection. (B) Time course analysis of tumor growth after s.c. injection of 1 × 105 Hdac1/2 conditional cells treated with either Ad-GFP or Ad-Cre. Eight animals were used in each group.
