Table 1.
Clinical Data on Patient Cohorts Used in this Study
| Rasmussen encephalitis cases | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Patient | Gender | Age at seizure onset (years) | Age at surgery (years) | Seizure duration (years) | Daily/Weekly seizures | Surgery type | Side | Area of sample | Seizure outcome |
| 1 | F | 7.5 | 8.5 | 1 | Daily | Hemispherectomy | Left | Central Operculum | Seizure free |
| Temporal Lobe | |||||||||
| 2 | M | 5.3 | 6.3 | 1 | Daily | Hemispherectomy | Right | Temporal and Neocortex | Seizure free |
| 3 | M | 2 | 14.3 | 12.3 | Daily | Hemispherectomy | Left | Frontal Lobe | Seizure free |
| 4 | F | 1 | 3.5 | 2.5 | Daily | Hemispherectomy | Right | Central Operculum | Seizure free |
| 5 | M | 4 | 4.7 | 0.7 | Daily | Hemispherectomy | Right | Central Operculum | Seizure free |
| Lateral Temporal Neocortex | |||||||||
| 6 | F | 7.5 | 7.6 | 0.1 | Daily | Hemispherectomy | Right | Central Operculum | Seizure free |
| 7 | F | 6.7 | 7.5 | 0.8 | Daily | Hemispherectomy | Right | Central Operculum | Seizure free |
| Lateral Temporal Neocortex | |||||||||
| Orbital-Frontal Neocortex | |||||||||
| 8 | M | 17 | 19 | 1.8 | Daily | Hemispherectomy | Right | Frontal Lobe | Seizure free |
| Central Operculum | |||||||||
| Cortical dysplasia controls | |||||||||
| Patient | Gender | Age at seizure onset (years) | Age at surgery (years) | Seizure duration (years) | Daily/Weekly seizures | Surgery type | Side | Area of sample | Seizure outcome |
| 1 | M | 0.8 | 3.5 | 2.7 | Daily | Hemispherectomy | Right | Central Operculum | Seizure free |
| 2 | F | 4 | 10.8 | 6.8 | Daily | Frontal focal resection | Right | Inferior Frontal, Middle Frontal Gyrus | No follow up |
| 3 | M | 0.33 | 2.4 | 2.1 | Daily | Hemispherectomy | Left | Central Operculum | Not seizure free |
| 4 | M | 0.84 | 4.5 | 3.7 | Daily | Frontal lobar resection | Right | Frontal Lobe | Seizure free |
| 5 | M | 4.8 | 7.4 | 2.6 | Daily | Frontal focal resection | Left | Frontal Lesion | Seizure free |
| 6 | F | 0.75 | 3.2 | 2.4 | Daily | Multilobar resection | Left | Fronto-Parietal Lobe | Seizure free |
| Tuberous sclerosis complex controls | |||||||||
| Patient | Gender | Age at seizure onset (years) | Age at surgery (years) | Seizure duration (years) | Daily/Weekly seizures | Surgery type | Side | Area of sample | Seizure outcome |
| 1 | F | 0 | 4 | 4 | Daily | Multilobar resection | Left | Parietal Tuber | Seizure free |
| 2 | M | 0.4 | 3.2 | 2.8 | Daily | Frontal tuber resection | Left | Frontal Cortex | Not seizure free |
| 3 | M | 0.25 | 5.5 | 5.2 | Daily | Frontal lobar resection | Left | Frontal Lobe | Not seizure free |
| 4 | M | 0.25 | 1.7 | 1.4 | Daily | Frontal tuber resection | Right | Frontal Tubor | Seizure free |
| 5 | F | 0.2 | 11.5 | 9.5 | Daily | Hemispherectomy | Right | Central Operculum | Not seizure free |
| 6 | M | 0 | 1.25 | 1.25 | Daily | Multilobar resection | Left | Parietal Occipital Lobe | Seizure free |