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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Apr 1;46(6):1027–1036. doi: 10.1016/j.yjmcc.2009.03.015

FIGURE 8. Kinetics of [Ca2+]mito vs. [Ca2+]i signals.

FIGURE 8

Aa, [Ca2+]mito and [Ca2+]i measured in line-scan images in permeabilized myocyte with mitochondrial rhod-2 and 5 μM cytosolic fura-2 salt (15 mM Na+, 80 μM cytochalasin D, 5 point smoothing). Ab, Time-to-Peak (rise time for either [Ca2+]mito or [Ca2+]i). Ac, Delay of [Ca2+]mito after [Ca2+]i as start-to-start and peak-to-peak, Ad, time constant τof decline. B, Curve fitting and expanded mitochondrial (black) and cytosolic (grey) transients indicated in Aa. C, Difference in mitochondrial and cytosolic kinetics (n=3 cells, 25 transients).