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. Author manuscript; available in PMC: 2009 May 17.
Published in final edited form as: J Law Med Ethics. 2008;36(3):449–457. doi: 10.1111/j.1748-720X.2008.290.x

Table 1. Baseline Variables Reported in Each of Papers Describing the Main Findings and Clinical Subgroup Analyses of V-HeFT I and V-HeFT II.

Baseline Variable Main Findings Subgroup Analyses
V-HeFT I V-HeFT II Clinical V-HeFT I Clinical V-HeFT II Racial V-HeFT I & II
Cohn et al. 19868 Cohn et al. 19919 Cohn et al. 198714 Johnson et al. 199315 Carson et al. 19997
Age + + + + +
Heart failure symptoms + + - - -
Angina in last month + - - - -
Coronary artery disease + + + + +
Previous myocardial infarction + + - - -
Alcohol excess + + + + -
Hypertension + + + + +
Diabetes + + - - -
Coronary bypass surgery + + + - -
Valve replacement surgery + - - - -
Vasodilator therapy + + + + -
Antiarrhythmic therapy + + + + -
Sublingual nitroglycerine + + - - -
Anticoagulant therapy + + - + -
Symptom score1 + - - - -
Arterial pressure + + - - -
Heart rate + + - + +2
Cardiothoracic ratio + + + + +
Ejection fraction + + + + +
Left ventricular internal diastolic diameter + + + + -
Exercise duration + - - - -
Maximum O2 consumption + + + + +
New York Heart Association class - + - + -
Race - + - - -
Cerebrovascular accident - + - - -
Tobacco use - + - - -
Atrial fibrillation - + - - -
S3 gallop - + - - -
Plasma norepinephrine - - - + +3
Plasma renin activity - - - + +3
Cardiac hospitalization - - - + -
Arrhythmia severity - - - + -
Weight - - - + -
Quality-of-life score - - - + -
Systolic blood pressure - - - + +
Diastolic blood pressure - - - + +
1

Sum of scores for dyspnea, fatigue, orthopnea, and paroxysmal nocturnal dyspnea

2

Only included in the racial subgroup analysis of V-HeFT I

3

Only included in the racial subgroup analysis of V-HeFT II