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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Exp Eye Res. 2008 Aug 26;88(2):307–313. doi: 10.1016/j.exer.2008.07.018

Figure 4.

Figure 4

Wnt 7b and α-smooth muscle actin localization in cultured and transgenic lenses. Representative images that include the anterior pole of lenses cultured with TGFβ2 and lenses of transgenic mice that overexpress TGFβ1 show strong immuno-reactivity for Wnt 7b and α-smooth muscle actin in anterior subcapsular plaques. Comparison with the lens epithelium of controls (insets; no exposure to TGFβ) shows immuno-reactivity for Wnt 7b is enhanced by exposure to TGFβ in both cultured and in transgenic lenses. Alpha-smooth muscle actin is prominent in patches within the plaques and merged images show colocalization with Wnt 7b only in some regions. α-SMA, α-smooth muscle actin. Scale bar: A–F, 60 μm.