TABLE 1.
Summary of data from cases of Cryptococcus laurentii infection in humans
| Year (reference) | Age (years) | Sex | Underlying condition(s) | Prior steroid exposure | Prior catheter use | Prior neutropenia | Clinical diagnosis | Clinical presentation | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| 1977 (2) | 40 | M | – | NR | NR | NR | Cutaneous infection | Cutaneous granuloma, regional lymph node enlargement | D-AmB | Resolved |
| 1980 (12) | 55 | F | Adenocarcinoma, dermatomyositis | Yes | NR | NR | Lung abscess | Asymptomatic right upper lobe cavitary lesion | D-AmB | Resolved |
| 1985 (16) | 37 | M | None known | NR | NR | NR | Pneumonia | NR | Surgery | Resolved |
| 1989 (17) | 13 | F | ESRD, peritoneal dialysis | NR | NR | NR | Peritonitis | Fever, abdominal pain, cloudy dialysate fluid | Catheter removal, D-AmB | Resolved |
| 1989 (18) | 14 | F | ESRD, peritoneal dialysis | NR | NR | NR | Peritonitis | Fever, abdominal pain, cloudy dialysate fluid | Catheter removal, peritoneal lavage with saline | Resolved |
| 1995 (11) | 61 | F | Chronic uveitis | Yes | NR | NR | Endophthalmitis | Deteriorating vision | Fluconazole | Resolved |
| 1997 (19) | 17 | M | Leukemia BMT | NR | Yes | Yes | Fungemia | Fever | Fluconazole | Resolved |
| 1997 (4) | 51 | NR | Diabetes, wore contact lenses | NR | NR | NR | Keratitis | Central corneal ulceration, central descemetocele with trace aqueous leak | Enucleation, D-AmB, miconazole | Resolved |
| 1997 (1) | <1 | M | Premature birth | NR | Yes | NR | Fungemia | Hypotension, tachycardia | Catheter removal, D-AmB | Resolved |
| 1997 (1) | 27 | F | Bacterial endocarditis | NR | Yes | NR | Fungemia | Fever, chills, painful cutaneous nodules | Catheter removal, fluconazole | Resolved |
| 1998 (3) | 34 | M | AIDS | NR | NR | NR | Meningitis | Hypotension, fever, dyspnea, headache, dizziness, diplopia | D-AmB, flucytosine | Resolved |
| 1998 (20) | 26 | M | Solid tumour | NR | Yes | Yes | Fungemia | NR | Catheter removal, fluconazole | Resolved |
| 1998 (20) | 50 | M | Non-Hodgkin lymphoma | Yes | Yes | Yes | Fungemia | NR | Catheter removal, D-AmB | Death |
| 1999 (20) | 57 | M | Acute myelogenous leukemia | Yes | Yes | Yes | Fungemia | NR | Catheter removal, D-AmB | Resolved |
| 2000 (21) | <1 | F | Premature birth | NR | Yes | No | Fungemia | Apnea, bradycardia, hypotension, hypothermia, abdominal distension | Catheter removal, D-AmB | Resolved |
| 2005 (PR) | 35 | F | AIDS, diabetes | NR | NR | NR | Pneumonia | Pleural effusion, fever, chest pain, cough, rales, crepitation, hepatosplenomegaly | Pleural drainage, fluconazole | Resolved |
BMT Bone marrow transplantation; D-AmB Deoxycholate amphotericin B; ESRD End-stage renal disease; F Female; M Male; NR Not reported; PR Present report