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Varenicline at doses of 0.01, 0.1, and 1.0 mg/kg does not affect contextual fear conditioning (Figure 1A). Deficits in contextual fear conditioning produced by withdrawal of chronic nicotine administration are ameliorated by varenicline (0.1 mg/kg) (Figure 1B). Significant difference (p < 0.05) from saline treated groups denoted with (*), significant difference (p < 0.05) from nicotine withdrawal groups denoted by (#).
