Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Exp Clin Psychopharmacol. 2008 Dec;16(6):458–474. doi: 10.1037/a0014103

Figure 5.

Figure 5

Effects of acute fenfluramine administration on dialysate serotonin (5-HT) levels measured in blood from conscious rats previously treated with chronic administration of fenfluramine (A) or fluoxetine (B). For chronic treatments, drugs were dissolved in sterile saline (fenfluramine) or 50% ethanol/saline (fluoxetine), and administered subcutaneously via osmotic minipumps for 2 weeks. On the day of test, fenfluramine was dissolved in saline and administered intravenously at 0 min. Serial blood samples were withdrawn at 15-min intervals and immediately dialyzed. 5-HT levels are mean ± SEM for N = 9/group. * p < .05 compared with saline controls at corresponding time points (Duncans post hoc test). Data taken from Zolkowska et al. (2008).