Table 2.
Ki Values of Test Drugs at 5-HT2 Receptors
| Drug | Human 5-HT2a | Human 5-HT2B | Human 5-HT2C |
|---|---|---|---|
| (±)-Fenfluramine | 5,216 ± 423 | 4,134 ± 1,281 | 3,183 ± 637 |
| (+)-Fenfluramine | 11,107 ± 2,303 | 5,099 ± 1173 | 6,245 ± 874 |
| (−)-Fenfluramine | 5,463 ± 600 | 5,713 ± 2,285 | 3,415 ± 922 |
| (±)-Norfenfluramine | 2,316 ± 278 | 52.1 ± 21 | 557 ± 61 |
| (+)-Norfenfluramine | 1,516 ± 150 | 11.2 ± 7.3 | 324 ± 12 |
| (−)-Norfenfluramine | 3,841 ± 614 | 47.8 ± 30.6 | 814 ± 98 |
| Ergotamine | 9.0 ± 1.0 | 3.0 ± 0.4 | 12 ± 1.5 |
| Methysergide | 15.0 ± 4.0 | 9.1 ± 4.9 | 1.8 ± 0.2 |
| Methylergonovine | 12.6 ± 1.0 | 0.49 ± 0.16 | 12.4 ± 1.0 |
| Fluoxetine | 299 ± 53 | 5,030 ± 1,960 | 50 ± 10 |
| Norfluoxetine | 638 ± 108 | 5,063 ± 1,974 | 286 ± 60 |
| Trazodone | 19.8 ± 2.4 | 73.6 ± 36 | 402 ± 44 |
| m-Chlorophenylpiperazine | 391 ± 47 | 3.2 ± 1.0 | 59 ± 11 |
| 5-HT | 614 ± 74 | 4.0 ± 1.9 | 12.2 ± 1.3 |
| Phentermine | >10,000 | >10,000 | >10,000 |
Note. Values are mean ± SD for n = 3 experiments. Data taken from Rothman, Baumann et al. (2000).