Figure 1.
A wound model was built in C57BL/B16 tumor-bearing mouse to determine the influence on melanoma by inflammation. When the tumor grew to 0.5 cm3, we created a wound beyond the tumor in the opposite site of the mouse's body. A.) The results show gradual reduction of the tumor volume when the wound was building; the tumor volume reached the minimum at day 7 (shown in black box, p < 0.01). After day 7, the tumor inhibitory effect of the wound (inflammation) weakened gradually. On about day 11 of the inflammatory group compared with the control group, tumor volume almost as same as the control group at day 13 (shown in black box, p > 0.05). B.) The cross-section of the tumor showed that the tumor necrosis with hemorrhage occurred in different proportions of times and groups. On day 7, the group wound tumors were smaller than the control group, and the area with necrotic tissue is greater than the control group (p < 0.01). After 11 days, the tumor volume in the wound group was increased, but in the cross-section area of necrotic tissue rather than in the control group (p > 0.05). The necrotic percentage after day 11 showed the tumor through a mechanism to adapt the wounds caused by inflammation induced necrosis, promoted the emergence of proliferation.