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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Genes Immun. 2009 Mar 5;10(3):201–209. doi: 10.1038/gene.2009.11

Figure 1.

Figure 1

Interplay between IFN-γ producing Th1 cells and IL-17-producing T-cells in psoriatic lesions. Interferon-γ produced by Th1 cells stimulates myeloid APCs and/or macrophages to produce IL-23, which together with IL-1, stimulates the survival and expansion of T-cells expressing IL-17 and/or IL-22. The entry of CD8+ T-cells expressing these cytokines into the epidermis is associated with increased epidermal hyperplasia and the production of innate immune peptides such as human β—defensin 2 (HBD-2). From 24, with permission.