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. Author manuscript; available in PMC: 2009 May 18.
Published in final edited form as: Cytokine Growth Factor Rev. 2007 Aug 1;18(5-6):511–518. doi: 10.1016/j.cytogfr.2007.06.021

Figure 4.

Figure 4

Conceptual diagram of STAT1 dynamics. STAT1 resides primarily in the cytoplasm prior to tyrosine phosphorylation, but following phosphorylation the STAT1 dimer is recognized by importin-α5. The active STAT1 dimer is imported into the nucleus and binds specific DNA targets. Bound to DNA the NES is masked, but following dissociation from DNA the NES is accessible to CRM1 and the protein is exported from the nucleus. The location of the NES and sequences required for NLS function are indicated in the DNA binding domain.