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. Author manuscript; available in PMC: 2009 May 18.
Published in final edited form as: Cytokine Growth Factor Rev. 2007 Aug 1;18(5-6):511–518. doi: 10.1016/j.cytogfr.2007.06.021

Figure 5.

Figure 5

Conceptual diagram of STAT2 dynamics. Unphosphorylated STAT2 in association with IRF-9 is imported into the nucleus via the NLS in IRF-9, however the strong constitutive NES in the carboxyl terminus of STAT2 redistributes the unphosphorylated STAT2 back to the cytoplasm. The unphosphorylated STAT2 is thereby constitutively shuttling in and out of the nucleus. Following tyrosine phosphorylation, STAT2 heterodimerizes with STAT1 and this leads to the gain of a NLS that is recognized by importin-α5 and the gain of an ability to bind DNA. Following dissociation from DNA STAT2 is actively exported from the nucleus.