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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Semin Radiat Oncol. 2009 Apr;19(2):122–132. doi: 10.1016/j.semradonc.2008.12.003

Fig. 9.

Fig. 9

The fractions of neurons in the dentate gyrus expressing Arc mRNA and Arc protein are reduced by irradiation. Mice received a single dose of 0 Gy or 10 Gy and 2 months later were allowed to explore a novel environment twice for 5 minutes with 25 minutes between sessions. Tissues were collected 5 minutes after the second exploration and Arc mRNA and Arc protein were detected using fluorescence in situ hybridization and immunohistochemistry, respectively. While there is a trend toward reduction in the fraction of neurons expressing Arc mRNA, the difference is significant with respect to the fraction of neurons expressing Arc protein. Each bar represents a mean of 3 animals; error bars are SEM.

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