Skip to main content
. Author manuscript; available in PMC: 2009 May 18.
Published in final edited form as: Brain Res Rev. 2008 Dec 31;60(1):2–23. doi: 10.1016/j.brainresrev.2008.12.018

Fig. 7.

Fig. 7

AP18 is a potent, selective and reversible antagonist for TRPA1. (a, b) AP18 inhibits increases in intracellular calcium evoked by cinnamaldehyde (Cinn; a; FLIPR technique) and iodoacetamide (IA; b; Fura-2 ratiometric calcium imaging) in CHO cells expressing TRPA1. (c) AP18 (20 μM) strongly inhibited the Cinn-activated TRPA1 currents in inside-out macropatches derived from Xenopus oocytes. The selectivity profile of AP18 is described in the box inset.