Fig. 7.

A, homology modeling of PXR.2. The trace of PXR.1 full-length in magenta. The 37 amino acids missing from PXR.2 are depicted in red. The green surface of hyperforin is shown behind. B, close-up view of Leu209 involved in the interaction with hyperforin in PXR.1. C, the PXR.2 homology model surface is displayed and colored in green, whereas the helix 12 is colored in magenta. The ligand hyperforin is displayed in ball-and-stick representation and colored by atom type (carbon gray, oxygen red).